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Article

The denatured state of N-PGK is compact and predominantly disordered.

Journal of molecular biology - 9 Jan 2009

Cliff Matthew J, Craven C Jeremy, Marston James P, Hounslow Andrea M, Clarke Anthony R, Waltho Jonathan P

Abstract excerpt

The organisation of the structure present in the chemically denatured N-terminal domain of phosphoglycerate kinase (N-PGK) has been determined by paramagnetic relaxation enhancements (PREs) to define the conformational landscape accessible to the domain. Below 2.0 M guanidine hydrochloride (GuHCl), a species of N-PGK (denoted I(b)) is detected, distinct from those previously characterised by kinetic experiments...

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Identifiers

PMID: 18948115
DOI: 10.1016/j.jmb.2008.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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