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Article

Non-Native α-Helices in the Initial Folding Intermediate Facilitate the Ordered Assembly of the β-Barrel in β-Lactoglobulin.

Biochemistry - 12 Sept 2017

Sakurai Kazumasa, Yagi Masanori, Konuma Tsuyoshi, Takahashi Satoshi, Nishimura Chiaki, Goto Yuji

Abstract excerpt

The roles of non-native α-helices frequently observed in the initial folding stage of β-sheet proteins have been examined for many years. We herein investigated the residue-level structures of several mutants of bovine β-lactoglobulin (βLG) in quenched-flow pH-pulse labeling experiments. βLG assumes a collapsed intermediate with a non-native α-helical structure (I0) in the early stage of folding, although its...

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PMID: 28795569
DOI: 10.1021/acs.biochem.7b00458

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