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Article

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.

Nucleic acids research - 1 Dec 2008

Jurkowska Renata Z, Anspach Nils, Urbanke Claus, Jia Da, Reinhardt Richard, Nellen Wolfgang, Cheng Xiaodong, Jeltsch Albert

Abstract excerpt

The C-terminal domains of Dnmt3a and Dnmt3L form elongated heterotetramers (3L-3a-3a-3L). Analytical ultracentrifugation confirmed the Dnmt3a-C/3L-C complex exists as a 2:2 heterotetramer in solution. The 3a-3a interface is the DNA-binding site, while both interfaces are essential for AdoMet binding and catalytic activity. Hairpin bisulfite analysis shows correlated methylation of two CG sites in a distance of...

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Identifiers

PMID: 18945701
DOI: 10.1093/nar/gkn747
PMCID: PMC2588524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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