Origins of H-2 polymorphism in the house mouse. II. Characterization of a model population and evidence for heterozygous advantage.

doi:10.1007/BF00205819

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Article

Origins of H-2 polymorphism in the house mouse. II. Characterization of a model population and evidence for heterozygous advantage.

Immunogenetics - 1 Jan 1991

Ritte U, Neufeld E, O'hUigin C, Figueroa F, Klein J

Abstract excerpt

Comparison of the rate of synonymous and nonsynonymous nucleotide substitutions suggests that certain regions of the functional H-2 genes, which are part of the mouse major histocompatibility complex (Mhc), are under strong positive selection pressure. Thus far, however, little evidence has been...

Topics

Animals
Female
Genotype
H-2 Antigens
Heterozygote
Male
Muridae
Polymorphism, Genetic
Population Dynamics

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