Article
Origins of H-2 polymorphism in the house mouse. II. Characterization of a model population and evidence for heterozygous advantage.
Immunogenetics - 1 Jan 1991
Ritte U, Neufeld E, O'hUigin C, Figueroa F, Klein J
Abstract excerpt
Comparison of the rate of synonymous and nonsynonymous nucleotide substitutions suggests that certain regions of the functional H-2 genes, which are part of the mouse major histocompatibility complex (Mhc), are under strong positive selection pressure. Thus far, however, little evidence has been provided for the existence of such pressure in natural mouse populations. We have, therefore, initiated experiments...
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