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Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway

21 Oct 2008

Abstract excerpt

The Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1), a functional homologue of the tumor necrosis factor receptor family, substantially contributes to EBV's oncogenic potential by activating nuclear factor-kappaB (NF-kappaB). miR-155 is an oncogenic miRNA critical for B-cell maturation and immunoglobulin production in response to antigen. We report that miR-155 expression is much higher in...

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PMID: 18940871
DOI: 10.1093/nar/gkn666

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