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Article

Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells

16 Jul 2018

Abstract excerpt

MicroRNA miR-155 is expressed at high levels in many human cancers, particularly lymphomas. Epstein-Barr virus (EBV) infects human B cells and drives the development of numerous lymphomas. Two genes carried by EBV (LMP1 and EBNA2) upregulate miR-155 expression, and miR-155 expression is required for the growth of EBV-infected B cells. We show that the EBV transcription factor EBNA2 upregulates miR-155 expression...

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PMID: 30021904
DOI: 10.1128/jvi.00716-18

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