Article
The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.
Biochemical and biophysical research communications - 12 Dec 2008
Gu Zhaodi, Mitsui Hidetoshi, Inomata Kenichi, Honda Masako, Endo Chiaki, Sakurada Akira, Sato Masami, Okada Yoshinori, Kondo Takashi, Horii Akira
Abstract excerpt
FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 beta-form promoter was observed in types B1 or higher (P=0.014). We propose a novel mechanism for the pathogenesis of...
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