Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples.

doi:10.1002/ajmg.b.30862

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Article

Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2009

Talkowski Michael E, McClain Lora, Allen Trina, Bradford L Dianne, Calkins Monica, Edwards Neil, Georgieva Lyudmila, Go Rodney, Gur Ruben, Gur Raquel, Kirov George, Chowdari Kodavali, Kwentus Joseph, Lyons Paul, Mansour Hader, McEvoy Joseph, O'Donovan Michael C, O'Jile Judith, Owen Michael J, Santos Alberto, Savage Robert, Toncheva Draga, Vockley Gerard, Wood Joel, Devlin Bernie, Nimgaonkar Vishwajit L

Abstract excerpt

Recessive mutations in the phenylalanine hydroxylase (PAH) gene predispose to phenylketonuria (PKU) in conjunction with dietary exposure to phenylalanine. Previous studies have suggested PAH variations could confer risk for schizophrenia, but comprehensive follow-up has not been reported. We analyzed 15 common PAH "tag" SNPs and three exonic variations that are rare in Caucasians but common in African-Americans...

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PMID: 18937293
DOI: 10.1002/ajmg.b.30862
PMCID: PMC2738981

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