Article
Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.
European journal of clinical pharmacology - 1 Mar 2009
Wang Yixi, Wang Changxi, Li Jiali, Wang Xueding, Zhu Genglong, Chen Xiao, Bi Huichang, Huang Min
Abstract excerpt
OBJECTIVE: The aim of this study was to assess the influence of the cytochrome (CYP450)3A5 and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem. METHODS: CYP3A5*3 (A6986G) and MDR1 C1236T, G2677T/A and C3435T polymorphisms were determined by PCR followed by restriction...
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