Article
[Isolation of CD44+/CD24 -/low and side population cells from MDA-MB-453 cells and the analysis of their activation of Wnt and Notch pathway].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences - 18 Oct 2008
Li Xin, Ren Jun
Abstract excerpt
OBJECTIVE: To explore stem cells phenotype of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer cells, MDA-MB-453 by isolation of CD44+CD24(-/low) and side population(SP). Analyze the relationship between SP cells and the gene amplification levels of the key proteins, beta-catenin and Notch-1 in Wnt and Notch signal pathways. And study the correlation of SP cells and the gene...
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