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Article

ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death.

Autophagy - 1 Nov 2008

Zhaorigetu Siqin, Wan Guanghua, Kaini Ramesh, Jiang Zeyu, Hu Chien-an A

Abstract excerpt

We recently reported the identification and characterization of a novel BH3-only pro-death protein, apolipoprotein L1 (ApoL1), that, when overexpressed, induces autophagic cell death (ACD) in a variety of cells, including those originated from normal and cancerous tissues. ApoL1 failed to induce ACD in autophagy-deficient Atg5(-/-) and Atg7(-/-) MEF cells, suggesting that ApoL1-induced cell death is indeed...

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Identifiers

PMID: 18927493
DOI: 10.4161/auto.7066
PMCID: PMC2659410

Genes

ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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