Article
Structure of the human gene for monoamine oxidase type A.
Nucleic acids research - 25 Aug 1991
Chen Z Y, Hotamisligil G S, Huang J K, Wen L, Ezzeddine D, Aydin-Muderrisoglu N, Powell J F, Huang R H, Breakefield X O, Craig I
Abstract excerpt
Monoamine oxidases, type A and type B, are principal enzymes for the degradation of biogenic amines, including catecholamines and serotonin. These isozymes have been implicated in neuropsychiatric disorders. Previously, cDNA clones for both MAO-A and MAO-B have been sequenced and the genes encoding them have been localized to human chromosome Xp11.23-Xp11.4. In this work, we isolated human genomic clones spanning...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- Exons
- Genetic Variation
- Humans
- Molecular Sequence Data
- Monoamine Oxidase
- Restriction Mapping
- X Chromosome