Article
A Functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly.
Behavior genetics - 1 Jan 2009
Bochdanovits Zoltán, Gosso Florencia M, van den Berg Linda, Rizzu Patrizia, Polderman Tinca J C, Pardo Luba M, Houlihan Lorna M, Luciano Michelle, Starr John M, Harris Sarah E, Deary Ian J, de Geus Eco J C, Boomsma Dorret I, Heutink Peter, Posthuma Danielle
Abstract excerpt
Comparative genomics offers a novel approach to unravel the genetic basis of complex traits. We performed a two stage analysis where genes ascertained for enhanced protein evolution in primates are subsequently searched for the presence of non-synonymous coding SNPs in the current human population at amino acid sites that differ between humans and chimpanzee. Positively selected genes among primates are generally...
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