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Article

A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performance.

PloS one - 1 Jan 2014

Yang Lixin, Zhang Rui, Li Ming, Wu Xujun, Wang Jianhong, Huang Lin, Shi Xiaodong, Li Qingwei, Su Bing

Abstract excerpt

As a product of the unique evolution of the human brain, human cognitive performance is largely a collection of heritable traits. Rather surprisingly, to date there have been no reported cases to highlight genes that underwent adaptive evolution in humans and which carry polymorphisms that have a marked effect on cognitive performance. IQ motif containing GTPase activating protein 1 (IQGAP1), a scaffold protein,...

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Identifiers

PMID: 25222038
DOI: 10.1371/journal.pone.0107065
PMCID: PMC4164536

Genes

IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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