Article
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study.
BMC medical genetics - 14 Oct 2008
Franceschini Nora, Almasy Laura, MacCluer Jean W, Göring Harald H H, Cole Shelley A, Diego Vincent P, Laston Sandra, Howard Barbara V, Lee Elisa T, Best Lyle G, Fabsitz Richard R, North Kari E
Abstract excerpt
BACKGROUND: Body fat mass distribution and deposition are determined by multiple environmental and genetic factors. Obesity is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes. We previously identified evidence for genotype-by-diabetes interaction on obesity traits in Strong Heart Family Study (SHFS) participants. To localize these genetic effects, we conducted genome-wide linkage scans...
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