[The association between angiogenin gene variations and familial amyotrophic lateral sclerosis in Chinese Han patients].

Abstract excerpt

OBJECTIVE: To investigate effect of genetic variants in angiogenin (ANG) on the susceptibility of familial amyotrophic lateral sclerosis (FALS) in Han Chinese. METHODS: Thirty-one FALS families from 2009 to 2012 were collected and ANG gene was screened in the probands using PCR and direct sequencing. RESULTS: All 31 ALS families were autosomal dominant inheritance. No mutations and single nucleotide polymorphism...

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