Article
The global regulator ArcA modulates expression of virulence factors in Vibrio cholerae.
Infection and immunity - 1 Oct 2003
Sengupta Nilanjan, Paul Kalidas, Chowdhury Rukhsana
Abstract excerpt
A Vibrio cholerae arcA mutant was constructed and used to examine the role of the global anaerobiosis response regulator ArcA in the expression of virulence factors in this important human pathogen. In V. cholerae, expression of the major virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) is regulated by the transcriptional activator ToxT. toxT expression, in turn, is controlled by the...
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