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Article

Binding site requirements of the virulence gene regulator AphB: differential affinities for the Vibrio cholerae classical and El Tor tcpPH promoters.

Molecular microbiology - 1 Apr 2002

Kovacikova Gabriela, Skorupski Karen

Abstract excerpt

The differential expression of virulence genes be-tween the two disease-causing biotypes of Vibrio cholerae, classical and El Tor, is primarily due to a single basepair change in the tcpPH promoter, which strongly influences the ability of the LysR regulator AphB to activate transcription in response to environmental conditions. We show here that this single basepair change influences virulence gene expression by...

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PMID: 11972789
DOI: 10.1046/j.1365-2958.2002.02914.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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