Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.

Journal of lipid research - 1 May 2014

Kuo Taiyi, Chen Tzu-Chieh, Yan Stephanie, Foo Fritz, Ching Cecilia, McQueen Allison, Wang Jen-Chywan

Abstract excerpt

Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis. In Angptl4 null mice, glucocorticoid-induced adipocyte lipolysis and hepatic steatosis are compromised. Markedly, insulin suppressed glucocorticoid-induced Angptl4 transcription. To unravel the mechanism,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiopoietins
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucocorticoids

Share to Insulin

Share to Lipid Metabolism

Share to Protein Transport

Share to Receptors, Glucocorticoid

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 24565756
DOI: 10.1194/jlr.M047860
PMCID: PMC3995469

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.PMID 24565756Read ↗

Genome-Wide Analysis of Glucocorticoid Receptor Binding Regions in Adipocytes Reveal Gene Network Involved in Triglyceride HomeostasisSemantic proximity Read ↗

The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic CellsSemantic proximity Read ↗

The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.Semantic proximity Read ↗

Coregulator Cell Cycle and Apoptosis Regulator 1 (CCAR1) Positively Regulates Adipocyte Differentiation through the Glucocorticoid Signaling PathwaySemantic proximity Read ↗

FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes.Semantic proximity Read ↗

Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammationSemantic proximity Read ↗

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretionSemantic proximity Read ↗

Hepatocyte nuclear factor 4a and glucocorticoid receptor coordinately regulate lipid metabolism in mice fed a high-fat-high-sugar dietSemantic proximity Read ↗

ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioningSemantic proximity Read ↗

Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose.Semantic proximity Read ↗

Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray studySemantic proximity Read ↗

Overexpression of the transcription factor Foxo4 is associated with rapid glucose clearance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.