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Article

Structurally Refined β‐Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors

10 Feb 2009

Abstract excerpt

Disarmed forces: Inhibition of the central virulence regulator ClpP by structurally refined beta-lactones resulted in dramatically reduced production of devastating virulence factors, including pyrogenic toxin superantigens derived from pathogenic multiresistant Staphylococcus aureus strains. Targeting of this virulence regulator could present an attractive strategy for neutralizing the harmful effects of...

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Share to Antimicrobial Peptides and Activities
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PMID: 19206121
DOI: 10.1002/cbic.200800743

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