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Article

Genome wide identification of recessive cancer genes by combinatorial mutation analysis.

PloS one - 1 Jan 2008

Volinia Stefano, Mascellani Nicoletta, Marchesini Jlenia, Veronese Angelo, Ormondroyd Elizabeth, Alder Hansjuerg, Palatini Jeff, Negrini Massimo, Croce Carlo M

Abstract excerpt

We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene deletions. We studied over 20,000 genes in 3 Gigabases of coding sequences and 700 array comparative genomic hybridizations. Recessive genes were scored according to...

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Identifiers

PMID: 18846217
DOI: 10.1371/journal.pone.0003380
PMCID: PMC2557123

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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