Article
Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2009
de Diego-Otero Yolanda, Romero-Zerbo Yanina, el Bekay Rajaa, Decara Juan, Sanchez Lourdes, Rodriguez-de Fonseca Fernando, del Arco-Herrera Ignacio
Abstract excerpt
Fragile X syndrome is the most common genetic cause of mental disability. The mechanisms underlying the pathogenesis remain unclear and specific treatments are still under development. Previous studies have proposed an abnormal hypothalamic-pituitary-adrenal axis and high cortisol levels are demonstrated in the fragile X patients. Additionally, we have previously described that NADPH-oxidase activation leads to...
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