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Article

Individual disease risk and multimetric analysis of Crohn disease.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2008

Gibson Jane, Collins Andrew, Morton Newton

Abstract excerpt

Rare dominant genes with high penetrance can be identified by linkage without inbreeding, whereas rare recessive genes with high penetrance are most efficiently recognized by autozygosity mapping of homozygotes in pedigrees with preferential inbreeding. On the contrary, complex inheritance is characterized by common genes with low penetrance, for which family studies and inbreeding are inefficient. Here, we...

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PMID: 18843111
DOI: 10.1073/pnas.0808009105
PMCID: PMC2564981

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