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Investigation of the role of the dopamine transporter in susceptibility to behavioural and psychological symptoms of patients with probable Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Pritchard Antonia L, Pritchard Colin W, Bentham Peter, Lendon Corinne L

Abstract excerpt

BACKGROUND/AIMS: Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investigation of the dopamine transporter (DAT1) gene in BPSD. METHODS: Our large cohort of 395 patients...

Topics

3' Untranslated Regions
Aged
Aged, 80 and over
Aggression
Alzheimer Disease
Cohort Studies
Depression
Dopamine Plasma Membrane Transport Proteins
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Irritable Mood

Longitudinal Studies

Male

Mental Disorders

Phenotype

Risk Factors

Source

Identifiers

PMID: 18841010
DOI: 10.1159/000160958

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