Article
Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease.
International journal of geriatric psychiatry - 1 Sept 2009
Pritchard Antonia L, Ratcliffe Laura, Sorour Eman, Haque Sayeed, Holder Roger, Bentham Peter, Lendon Corinne L
Abstract excerpt
OBJECTIVE: Alzheimer's disease (AD) patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to the development of BPSD in AD has been supported. Polymorphisms within dopamine receptors DRD1, DRD2, DRD3 and DRD4 have previously been investigated in a few interesting studies that are reviewed here and extended using our patient cohort. METHODS: Our large cohort...
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