Familial hypercholesterolaemia: underdiagnosed and undertreated

Abstract excerpt

Autosomal dominant familial hypercholesterolaemia (FH) is the most common inherited disorder known to cause premature coronary heart disease in people of European descent. The estimated prevalence of FH is 1 in 500, and heterozygous FH carries a high risk of premature coronary disease if left untreated (>50% risk in men by the age of 50 and >30% in women by 60 years). However, the condition is underdiagnosed and...

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