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Article

Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine.

Frontiers in cellular and infection microbiology - 1 Jan 2018

Ou Xumin, Wang Mingshu, Mao Sai, Cao Jingyu, Cheng Anchun, Zhu Dekang, Chen Shun, Jia Renyong, Liu Mafeng, Yang Qiao, Wu Ying, Zhao Xinxin, Zhang Shaqiu, Liu Yunya, Yu Yanling, Zhang Ling, Chen Xiaoyue, Peppelenbosch Maikel P, Pan Qiuwei

Abstract excerpt

Live attenuated vaccines are widely used to protect humans or animals from pathogen infections. We have previously developed a chicken embryo-attenuated Duck Hepatitis A Virus genotype 1 (DHAV-1) vaccine (CH60 strain). This study aims to understand the mechanisms that drive a virulent strain to an attenuated virus. Here, we systematically compared five DHAV-1 chicken embryo attenuated strains and 68 virulent...

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Identifiers

PMID: 30073153
DOI: 10.3389/fcimb.2018.00249
PMCID: PMC6058041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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