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Cancer diagnostic classifiers based on quantitative DNA methylation

21 Mar 2014

Abstract excerpt

Epigenetic change is part of the carcinogenic process and a deep reservoir for biomarker discovery. Reversible methylation of cytosines is noteworthy because it can be measured accurately and easily by various molecular methods and DNA methylation patterns are linked to important tumourigenic pathways. Clinically relevant methylation changes are known in common human cancers such as cervix, prostate, breast,...

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PMID: 24649818
DOI: 10.1586/14737159.2014.897610

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