Altered fibrin clot structure and function in the healthy first-degree relatives of subjects with intermittent claudication.

Abstract excerpt

OBJECTIVE: Studies report clustering of cardiovascular risk factors and increased cardiovascular events in healthy first-degree relatives (FDR) of subjects with intermittent claudication (IC). Family history is an independent risk factor in coronary artery disease but the role of genetic factors is undefined in peripheral arterial disease. The fibrin clot is the final product of the atherothrombotic process and...

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