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Use of Biological Therapy to Enhance Both Virotherapy and Adoptive T-Cell Therapy for Cancer

30 Sept 2008

Abstract excerpt

To protect viral particles from neutralization, sequestration, nonspecific adhesion, and mislocalization following systemic delivery, we have previously exploited the natural tumor-homing properties of antigen-specific CD8+ T cells. Thus, OT-I T cells, preloaded in vitro with the oncolytic vesicular stomatitis virus (VSV), can deliver virus to established B16ova tumors to generate significantly better therapy...

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Identifiers

PMID: 18827807
DOI: 10.1038/mt.2008.212

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