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Article

Synergistic Interaction Between Oncolytic Viruses Augments Tumor Killing

16 Mar 2010

Abstract excerpt

A major barrier to all oncolytic viruses (OVs) in clinical development is cellular innate immunity, which is variably active in a spectrum of human malignancies. To overcome the heterogeneity of tumor response, we combined complementary OVs that attack cancers in distinct ways to improve therapeutic outcome. Two genetically distinct viruses, vesicular stomatitis virus (VSV) and vaccinia virus (VV), were used to...

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PMID: 20234341
DOI: 10.1038/mt.2010.44

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