Article
Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations.
American journal of respiratory and critical care medicine - 15 Nov 2008
Vergara Candelaria, Tsai Yuhjung J, Grant Audrey V, Rafaels Nicholas, Gao Li, Hand Tracey, Stockton Maria, Campbell Monica, Mercado Dilia, Faruque Mezbah, Dunston Georgia, Beaty Terri H, Oliveira Ricardo Riccio, Ponte Eduardo V, Cruz Alvaro A, Carvalho Edgar, Araujo Maria Ilma, Watson Harold, Schleimer Robert P, Caraballo Luis, Nickel Renate G, Mathias Rasika A, Barnes Kathleen C
Abstract excerpt
RATIONALE: Asthma prevalence and severity are high among underserved minorities, including those of African descent. The Duffy antigen/receptor for chemokines is the receptor for Plasmodium vivax on erythrocytes and functions as a chemokine-clearing receptor. Unlike European populations, decreased expression of the receptor on erythrocytes is common among populations of African descent, and results from a...
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