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Article

Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.

Brain research - 3 Dec 2008

Senechal Yann, Prut Laetitia, Kelly Peter H, Staufenbiel Matthias, Natt Francois, Hoyer Daniel, Wiessner Christoph, Dev Kumlesh K

Abstract excerpt

Genetic abnormalities in amyloid precursor protein (APP) are associated with Down's syndrome and familial Alzheimer's disease where hallmark plaques contain A beta peptides derived from APP. Both APP and its derivatives are implicated in neurodegenerative processes and may play important physiolo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18823960
DOI: 10.1016/j.brainres.2008.09.024

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18823960-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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