Article
Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.
Brain research - 3 Dec 2008
Senechal Yann, Prut Laetitia, Kelly Peter H, Staufenbiel Matthias, Natt Francois, Hoyer Daniel, Wiessner Christoph, Dev Kumlesh K
Abstract excerpt
Genetic abnormalities in amyloid precursor protein (APP) are associated with Down's syndrome and familial Alzheimer's disease where hallmark plaques contain A beta peptides derived from APP. Both APP and its derivatives are implicated in neurodegenerative processes and may play important physiological and pathophysiological roles in synaptic function. Here, we show that young APP23 transgenic mice overexpressing...
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