Article
Interpretation of phenotype in genetically engineered mice.
Laboratory animal science - 1 Apr 1999
Doetschman T
Abstract excerpt
BACKGROUND AND PURPOSE: In mice, genetic engineering involves two general approaches-addition of an exogenous gene, resulting in transgenic mice, and use of knockout mice, which have a targeted mutation of an endogenous gene. The advantages of these approaches is that questions can be asked about the function of a particular gene in a living mammalian organism, taking into account interactions among cells,...
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