Article
The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor.
BMC cancer - 29 Sept 2008
Ashton Katie A, Proietto Anthony, Otton Geoffrey, Symonds Ian, McEvoy Mark, Attia John, Gilbert Michael, Hamann Ute, Scott Rodney J
Abstract excerpt
BACKGROUND: Cyclin D1 is integral for the G1 to S phase of the cell cycle as it regulates cellular proliferation. A polymorphism in cyclin D1, 870 G>A, causes overexpression and supports uncontrollable cellular growth. This polymorphism has been associated with an increased risk of developing many cancers, including endometrial cancer. METHODS: The 870 G>A polymorphisms (rs605965) in the cyclin D1 gene was...
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