Article
Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2008
Grifone Raphälle, Jarry Thérèse, Dandonneau Mathieu, Grenier Julien, Duprez Delphine, Kelly Robert G
Abstract excerpt
Vertebrate craniofacial and trunk myogenesis are regulated by distinct genetic programs. Tbx1, homologue of the del22q11.2 syndrome candidate gene TBX1, controls branchiomeric craniofacial muscle development. Here, we demonstrate using immunohistochemistry that myogenic regulatory factors are activated in Tbx1-positive cells within pharyngeal mesoderm. These cells are also Islet1 and Capsulin-positive and in the...
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