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LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

31 Aug 2018

Abstract excerpt

Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA H19 increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of H19 with...

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PMID: 30190464
DOI: 10.1038/s41467-018-05933-8

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