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Article

Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate

25 Sept 2008

Abstract excerpt

Specification of endothelial cell (EC) fate during vascular development is controlled by distinct key regulators. While Notch plays an essential role in induction of arterial phenotypes, COUP-TFII is required to maintain the venous EC identity. Homeodomain transcription factor Prox1 functions to reprogram venous ECs to lymphatic endothelial cells (LECs). Here, we report that the venous EC fate regulator COUP-TFII...

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Identifiers

PMID: 18815287
DOI: 10.1182/blood-2008-03-145789

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