Article
Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression.
Experimental hematology - 1 Dec 2008
Barroga Charlene F, Pham Hang, Kaushansky Kenneth
Abstract excerpt
OBJECTIVE: Mice harboring c-Myb hypomorphic mutations display enhanced thrombopoiesis because of increased numbers of megakaryocytes and their progenitors. Thrombopoietin induces these same effects, which lead us to hypothesize that the hormone acts through modulation of c-Myb expression, as c-Myb levels falls during thrombopoietin-induced megakaryocyte (MK) maturation. Micro RNAs (miRs) downregulate gene...
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