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Article

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2008

Shuda Masahiro, Feng Huichen, Kwun Hyun Jin, Rosen Steven T, Gjoerup Ole, Moore Patrick S, Chang Yuan

Abstract excerpt

Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of Pittsburgh that is monoclonally integrated into the genome of approximately 80% of human Merkel cell carcinomas (MCCs). Transcript mapping was performed to show that MCV expresses transcripts in MCCs similar to large T (LT), small T (ST), and 17kT transcripts of SV40. Nine MCC tumor-derived LT genomic sequences have been...

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Share to Antigens, Viral, Tumor
Share to Carcinoma, Merkel Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Conserved Sequence

Share to Polyomavirus

Share to Sequence Alignment

Share to Transcription, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 18812503
DOI: 10.1073/pnas.0806526105
PMCID: PMC2551627

Genes

MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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