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Article

Polymorphisms in the heparanase gene in multiple myeloma association with bone morbidity and survival.

European journal of haematology - 1 Jan 2015

Andersen Niels F, Vogel Ulla, Klausen Tobias W, Gimsing Peter, Gregersen Henrik, Abildgaard Niels, Vangsted Annette J

Abstract excerpt

OBJECTIVES: In multiple myeloma, heparanase (HSPE) is involved in myeloma cell growth, angiogenesis, osteoclastogenesis and shedding of syndecan-1, a key player in myeloma pathophysiology. Different single nucleotide polymorphisms (SNPs) in the HSPE gene with effect on gene function have been described, and some are associated with haematological malignancies. METHODS: In this study, we evaluated four SNPs...

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Identifiers

PMID: 24954766
DOI: 10.1111/ejh.12401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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