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Article

Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.

Journal of cellular physiology - 1 Jun 2006

Kram Vardit, Zcharia Eyal, Yacoby-Zeevi Oron, Metzger Shula, Chajek-Shaul Tova, Gabet Yankel, Müller Ralph, Vlodavsky Israel, Bab Itai

Abstract excerpt

Heparan sulfate proteoglycans (HSPGs) are ubiquitous macromolecules. In bone, they are associated with cell surfaces and the extracellular matrix (ECM). The heparan sulfate (HS) chains of HSPGs bind a multitude of bioactive molecules, thereby controlling normal and pathologic processes. The HS-degrading endoglycosidase, heparanase, has been implicated in processes such as inflammation, vascularization associated...

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Identifiers

PMID: 16514606
DOI: 10.1002/jcp.20625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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