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Article

In vitro and in vivo validation of ligA and tarI as essential targets in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Dec 2008

Streker Karin, Schäfer Tina, Freiberg Christoph, Brötz-Oesterhelt Heike, Hacker Jörg, Labischinski Harald, Ohlsen Knut

Abstract excerpt

A conditional expression system has been developed using the isopropyl-beta-d-thiogalactopyranoside (IPTG)-inducible Pspac promoter to validate essential genes of Staphylococcus aureus in vivo. The system has been applied to prove the essentiality of ligA and to evaluate the function of tarI, which was found to be essential in vitro but not in vivo.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18809938
DOI: 10.1128/AAC.00548-07
PMCID: PMC2592864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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