Article
Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture.
The Journal of infectious diseases - 15 Nov 2008
Nsobya Samuel L, Kiggundu Moses, Joloba Moses, Dorsey Grant, Rosenthal Philip J
Abstract excerpt
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture from 1.73 to 1.56. New strains appeared after day 0 in 20 cultures. Strains disappeared after day 0 in 56% of 45 cultures that were initially mixed; persisting strains more commonly had...
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