Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism.

doi:10.1074/jbc.M105372200

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Article

Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism.

The Journal of biological chemistry - 21 Jun 2002

Corsi Barbara, Cozzi Anna, Arosio Paolo, Drysdale Jim, Santambrogio Paolo, Campanella Alessandro, Biasiotto Giorgio, Albertini Alberto, Levi Sonia

Abstract excerpt

Mitochondrial ferritin (MtF) is a newly identified ferritin encoded by an intronless gene on chromosome 5q23.1. The mature recombinant MtF has a ferroxidase center and binds iron in vitro similarly to H-ferritin. To explore the structural and functional aspects of MtF, we expressed the following forms in HeLa cells: the MtF precursor (approximately 28 kDa), a mutant MtF precursor with a mutated ferroxidase...

Topics

Blotting, Western
Cell Line
Cytosol
Electrophoresis, Polyacrylamide Gel
Ferritins
HeLa Cells
Humans
Introns
Iron
Iron Deficiencies
Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondria

Mutation

Plasmids

Precipitin Tests

Protein Binding

Receptors, Transferrin

Time Factors

Source

Open in PubMed

Identifiers

PMID: 11953424
DOI: 10.1074/jbc.M105372200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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