Article
PMCHAP: a new approach for haplotype inference using nuclear families with only one parent and multiple offspring.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie - 1 Oct 2008
Ding X D, Zhang Q, Simianer H
Abstract excerpt
A new approach is suggested to perform joint haplotype reconstruction and haplotype frequency estimation in families consisting of multiple full sibs where only one parent is genotyped. It can also deal with the mixed data structures with 0 and 1 parent genotyped. The approach is based on the maximum likelihood principle using the expectation-maximization algorithm and thus combines pedigree information within...
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