Article
Generation of a conditional null allele for Cftr in mice.
Genesis (New York, N.Y. : 2000) - 1 Oct 2008
Hodges Craig A, Cotton Calvin U, Palmert Mark R, Drumm Mitchell L
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes a cAMP-regulated chloride channel that is important in controlling the exchange of fluid and electrolytes across epithelial cells. Mutation of CFTR can lead to cystic fibrosis (CF), the most common lethal genetic disease in Caucasians. CF is a systemic illness with multiple organ systems affected including pulmonary, gastrointestinal,...
Topics
- Alleles
- Animals
- Cell Line
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Disease Models, Animal
- Electrophysiological Phenomena
- Female
- Integrases
- Male
- Mice