Cystic fibrosis in the mouse by targeted insertional mutagenesis.

doi:10.1038/359211a0

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Article

Cystic fibrosis in the mouse by targeted insertional mutagenesis.

Nature - 17 Sept 1992

Dorin J R, Dickinson P, Alton E W, Smith S N, Geddes D M, Stevenson B J, Kimber W L, Fleming S, Clarke A R, Hooper M L

Abstract excerpt

Cystic fibrosis is a fatal genetic disorder which afflicts 50,000 people worldwide. A viable animal model would be invaluable for investigating and combating this disease. The mouse cystic fibrosis transmembrane conductance regulator gene was disrupted in embryonal stem cells using an insertional...

Topics

Animals
Biological Transport
Chimera
Chlorine
Chromosome Mapping
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Disease Models, Animal
Female
Genes, Regulator
Genotype
Male
Membrane Potentials
Membrane Proteins
Mice
Mice, Inbred Strains
Mutagenesis, Insertional

Source

Open in PubMed

Identifiers

PMID: 1382232
DOI: 10.1038/359211a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1382232-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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