Article
An animal model for cystic fibrosis made by gene targeting.
Science (New York, N.Y.) - 21 Aug 1992
Snouwaert J N, Brigman K K, Latour A M, Malouf N N, Boucher R C, Smithies O, Koller B H
Abstract excerpt
Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known as the cystic fibrosis transmembrane conductance regulator (CFTR). To create an animal model for cystic fibrosis, mice were generated from embryonic stem cells in which...
Topics
- Animals
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Digestive System
- Disease Models, Animal
- Exocrine Glands
- Gallbladder
- Genitalia, Male
- Genotype
- Growth
- Intestinal Obstruction
- Liver
- Male
- Meconium
- Membrane Proteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL