Article
In-frame elimination of exon 10 in Cftrtm1Unc CF mice.
Gene - 28 Apr 1998
Xu Z, Gupta V, Lei D, Holmes A, Carlson E, Gruenert D C
Abstract excerpt
Cystic fibrosis (CF) is a severe autosomal-linked inherited disease in humans. Transgenic CF animals play a crucial role in the study of molecular mechanisms underlying disease pathology. In the present study, CFTR mRNA expression was examined in different tissues from one CF mouse model that con...
Topics
- Animals
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA Mutational Analysis
- Disease Models, Animal
- Exons
- Gene Expression
- Genotype
- Heterozygote
- Homozygote
- Mice
- Mice, Knockout
- Mice, Transgenic
- Polymerase Chain Reaction
- RNA, Messenger
- Sequence Analysis, DNA
- Sequence Deletion