Article
In-frame elimination of exon 10 in Cftrtm1Unc CF mice.
Gene - 28 Apr 1998
Xu Z, Gupta V, Lei D, Holmes A, Carlson E, Gruenert D C
Abstract excerpt
Cystic fibrosis (CF) is a severe autosomal-linked inherited disease in humans. Transgenic CF animals play a crucial role in the study of molecular mechanisms underlying disease pathology. In the present study, CFTR mRNA expression was examined in different tissues from one CF mouse model that contains a disruption in exon 10 sequence of the CF transmembrane conductance regulator (CFTR) gene. Multiple tissue...
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